DEINOGESTEROL PLUS

Deinogesterol Plus is a fixed-dose combination oral contraceptive tablet that pairs Dienogest, a highly selective fourth-generation progestin, with Ethinyloestradiol, a synthetic estrogen commonly used in modern hormonal contraceptives. Together, these two hormones work synergistically to prevent ovulation and provide reliable, reversible contraception when taken as directed. Manufactured by Steris Healthcare, this formulation is prescribed by gynecologists and general physicians across India for women seeking effective, well-tolerated hormonal contraception, as well as for select non-contraceptive therapeutic benefits associated with this hormone combination.

Product Information

Why It's Important

Access to safe, effective, and well-tolerated contraception remains a cornerstone of reproductive healthcare for women across India. Unintended pregnancies carry significant personal, social, and health consequences, and combined oral contraceptives remain one of the most widely used, extensively studied, and reliable methods of reversible birth control available today, when used correctly and consistently.

Deinogesterol Plus holds particular clinical relevance because of its progestin component, Dienogest — a fourth-generation progestin known for its high selectivity for the progesterone receptor and its notably favorable antiandrogenic profile compared to older-generation progestins. This means that, alongside contraceptive efficacy, many women using Dienogest-based combined pills experience meaningful improvement in hormonal acne, reduced menstrual pain, and more predictable, often lighter periods — benefits that extend well beyond contraception alone and can significantly improve quality of life for women with cycle-related symptoms.

Menstrual irregularities and heavy or painful periods are extremely common complaints in gynecological practice, often leading to missed workdays, reduced productivity, and significant discomfort. A well-formulated, low-dose combined oral contraceptive like Deinogesterol Plus offers physicians a dual-purpose tool — reliable contraception paired with meaningful symptomatic relief — making it a frequently reached-for option in everyday gynecological and family planning practice.

Key Benefits 

What Are the Benefits of Deinogesterol Plus?

Dienogest 2mg + Ethinyloestradiol 30mcg, as formulated in Deinogesterol Plus, offers several clinically meaningful advantages:

• Highly effective contraception: When taken correctly and consistently, combined oral contraceptives containing Dienogest and Ethinyloestradiol offer one of the most reliable reversible methods of pregnancy prevention available.
• Improved menstrual cycle regularity: This combination helps establish predictable, regular withdrawal bleeding, which can be particularly beneficial for women with previously irregular or unpredictable cycles.
• Reduction in menstrual blood loss: Many women experience lighter periods while on this combination, offering relief for those affected by heavy menstrual bleeding.
• Antiandrogenic benefit for skin health: Dienogest's selective antiandrogenic activity often contributes to visible improvement in hormonal acne and, in some cases, mild hirsutism, over the course of treatment.
• Reduced menstrual pain: Many users report a noticeable reduction in dysmenorrhea (period pain), improving day-to-day comfort during menstruation.
• Non-contraceptive endometrial protection: Like other combined oral contraceptives, this formulation offers protective effects against endometrial hyperplasia associated with unopposed estrogen exposure.
• Convenient, well-established dosing regimen: The standard 21-tablet cycle format is well understood by both physicians and patients, supporting ease of use and predictable follow-up.
• Trusted manufacturing standards: Deinogesterol Plus is manufactured by Steris Healthcare, a WHO-GMP and ISO 9001:2018 certified pharmaceutical company, ensuring consistent hormone potency and reliable contraceptive performance across every batch.

Side Effects 

As with all combined oral contraceptives, Deinogesterol Plus may cause side effects, particularly during the first few months as the body adjusts. Common side effects include:

• Nausea, particularly when tablets are taken on an empty stomach
• Headache
• Breast tenderness or mild swelling
• Mood changes or irritability
• Breakthrough bleeding or spotting, especially in the first few cycles
• Mild weight fluctuation
• Reduced libido in some users
• Mild fluid retention

Most of these effects tend to improve within the first two to three cycles as the body adapts to the hormonal regimen, and many can be minimized by taking the tablet at a consistent time each day, ideally with food.

Precautions & Warnings

Before starting Deinogesterol Plus, patients and prescribers should carefully consider the following precautions:

• Smoking and Age: Women over 35 who smoke face a significantly elevated risk of serious cardiovascular complications and are generally advised against combined oral contraceptive use.
• History of Blood Clots: Should not be used in women with a personal or strong family history of venous thromboembolism, stroke, or heart attack, unless specifically cleared by a specialist.
• Migraine with Aura: Combined oral contraceptives are generally contraindicated in women who experience migraine with aura due to increased stroke risk.
• Uncontrolled Hypertension: Blood pressure should be well controlled and monitored before and during use.
• Liver Disease: Should be avoided in women with significant liver disease or a history of hormone-related liver tumors.
• Breast Cancer History: Contraindicated in women with current or past hormone-sensitive breast cancer.
• Pregnancy: Should not be used if pregnancy is confirmed or suspected.
• Diabetes with Vascular Complications: Requires careful risk assessment in women with long-standing diabetes affecting blood vessels.
• Drug Interactions: Certain medications, including some antibiotics, anticonvulsants, and herbal supplements like St. John's Wort, may reduce contraceptive effectiveness and should be disclosed to the prescribing physician.
• Regular Health Checks: Periodic blood pressure monitoring and routine gynecological review are recommended throughout use.

Mechanism of Action 

Deinogesterol Plus works through the combined hormonal action of its two active components:

1. Suppression of Ovulation: Both Dienogest and Ethinyloestradiol act on the hypothalamic-pituitary-ovarian axis to suppress the release of gonadotropin-releasing hormone (GnRH), reducing luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion, which in turn prevents ovulation.
2. Thickening of Cervical Mucus: Dienogest's progestational activity increases the viscosity of cervical mucus, creating a barrier that impedes sperm penetration into the uterine cavity.
3. Alteration of the Endometrial Lining: The combination alters the endometrium, making it less receptive to implantation, which serves as an additional contraceptive mechanism.
4. Selective Progesterone Receptor Binding: Dienogest is highly selective for the progesterone receptor with minimal androgenic, estrogenic, or glucocorticoid receptor activity, which is responsible for its favorable antiandrogenic side-effect profile compared to older progestins.
5. Cycle Stabilization: The steady, combined hormonal exposure throughout the 21-day active phase helps stabilize the endometrial lining, contributing to more predictable, often lighter withdrawal bleeding during the pill-free interval.

This combined, multi-level mechanism is what makes Dienogest and Ethinyloestradiol tablets both a highly effective contraceptive and a therapeutically useful option for women experiencing hormone-related menstrual cycle disturbances.

Frequently Asked Questions (FAQ)

1. Where can I buy Dienogest and Ethinylestradiol Tablets online?
You can purchase Dienogest and Ethinylestradiol Tablets through licensed online pharmacies or authorized pharmaceutical suppliers. Verify the strength, manufacturer, batch number, expiry date, and packaging before purchasing.

2. What is the price of Dienogest and Ethinylestradiol Tablets?
The price may vary depending on the brand, strength, pack size, manufacturer, seller, and applicable pharmacy charges. Check the current listed price before ordering.

3. Can I order Dienogest and Ethinylestradiol Tablets online?
Yes, these tablets can be ordered online where legally available. Since they contain hormonal medicines, a valid prescription may be required depending on the formulation and applicable regulations.

4. Is Dienogest and Ethinylestradiol Tablets available from Steris Healthcare?
Availability depends on Steris Healthcare's current product range and stock status. Contact Steris Healthcare or an authorized distributor to confirm availability, strength, pack size, and ordering details.

5. What is Dienogest and Ethinylestradiol Tablets used for?
Dienogest and Ethinylestradiol Tablets are hormonal medicines used for contraception. Depending on the specific formulation, they may also be prescribed to help manage certain menstrual symptoms or hormone-related conditions.

6. What is the composition of Dienogest and Ethinylestradiol Tablets?
The tablets contain Dienogest and Ethinylestradiol as active ingredients. The exact strength and inactive ingredients depend on the specific product formulation.

7. Is a prescription required?
Prescription requirements may vary according to the formulation and local regulations. These hormonal tablets should be used under the guidance of a qualified healthcare professional.

8. How should Dienogest and Ethinylestradiol Tablets be taken?
Take the tablets exactly as prescribed and follow the pack instructions carefully. Take them at approximately the same time each day and follow the recommended schedule. Do not change or stop treatment without medical advice.

9. What should I know before buying Dienogest and Ethinylestradiol Tablets?
Before buying, verify the exact composition, strength, manufacturer, batch number, expiry date, packaging, and storage instructions. Tell your doctor about a history of blood clots, migraine with aura, liver disease, cardiovascular problems, smoking, pregnancy, or other medicines you are taking.

10. How can I order Dienogest and Ethinylestradiol Tablets online?
Order through a licensed online pharmacy or authorized pharmaceutical supplier. Select the prescribed formulation and pack size, provide a prescription if required, and verify the product and delivery details before completing your purchase.