BOSENTIME 125

BOSENTIME 125 is a prescription-only tablet containing bosentan 125 mg, made and marketed in India by Steris Healthcare Pvt. Ltd. Bosentan is an oral endothelin receptor antagonist used to treat pulmonary arterial hypertension (PAH), a serious condition in which the blood vessels of the lungs narrow and the right side of the heart works under strain. The 125 mg strength is the usual adult maintenance dose, taken twice daily, once a specialist has started treatment at a lower dose and confirmed that liver tests are acceptable. 

BOSENTIME 125 Product Information

Detail	Information
Brand name	BOSENTIME 125
Composition	Bosentan 125 mg
Product form	Tablet
Pack size	Strip of 10 tablets
Drug class	Dual endothelin receptor antagonist
Primary use	Pulmonary arterial hypertension (PAH)
Manufacturer / Marketer	Steris Healthcare Pvt. Ltd.
Prescription status	Schedule H – prescription only
Storage	Store as directed on the pack, away from moisture, heat and children
Price	[MRP PER STRIP OF 10 TABLETS – PLACEHOLDER, to be confirmed by Steris commercial team]

What Is BOSENTIME 125 and What Is Bosentan Used For?

If you or a family member has been prescribed bosentan, you probably have questions about what it does, how it is taken, what safety checks are needed and where to obtain it reliably in India. This page answers those questions in plain language and is written to support a conversation with your treating specialist, not replace it.

BOSENTIME 125 contains bosentan 125 mg in each tablet. It belongs to the class of medicines called dual endothelin receptor antagonists (ERAs). Bosentan is prescribed mainly for pulmonary arterial hypertension (WHO Group 1 pulmonary hypertension), a rare, chronic and progressive condition. In PAH, the small arteries in the lungs become narrow and stiff. Blood pressure inside the lung circulation rises, the right side of the heart has to pump harder, and over time people notice breathlessness, tiredness, dizziness, chest discomfort and swelling of the ankles.

Bosentan is a long-term therapy. It is not a rescue medicine and does not give instant relief, so it is taken every day at the times your doctor advises.

Clinical Indications at a Glance

Indication	How bosentan is used	Notes
Pulmonary arterial hypertension (WHO Group 1) in adults	To improve exercise capacity and reduce symptoms	Suitability by WHO functional class is decided by the specialist per the approved labelling
Digital ulcers in systemic sclerosis (scleroderma)	To help reduce the number of new finger ulcers	Included in some approved labelling; confirm against the Indian package insert
PAH in children	Weight-based dosing under specialist care	125 mg is generally an adult-strength tablet; do not give it to a child unless a specialist prescribes it

How Does Bosentan Work? 

Your body makes a natural chemical called endothelin-1. It tightens (constricts) blood vessels and encourages the vessel wall to thicken and remodel. In people with PAH, endothelin-1 levels in the lungs are higher than normal, which contributes to narrowed, stiffened pulmonary arteries.

Bosentan blocks both endothelin receptor types (ET-A and ET-B). By reducing endothelin's effect on the vessel wall, bosentan helps the pulmonary arteries relax, lowers the resistance the heart has to pump against and can improve how far and how comfortably a person can walk. Because the medicine acts on the underlying pathway rather than only on symptoms, it is usually taken continuously rather than only when breathless.

Key Benefits of BOSENTIME 125

• Targets a root pathway of PAH: blocks endothelin signalling in the lung blood vessels.
• Oral, tablet-based therapy: an option for long-term outpatient treatment when prescribed.
• Improves exercise capacity: approved to improve the ability to walk and carry out daily activity in suitable patients. [CLINICAL STATISTIC PLACEHOLDER – reviewer to insert pivotal trial data (e.g., change in 6-minute walk distance) with citation.]
• Flexible in combination: specialists sometimes combine bosentan with other PAH drug classes, based on the patient's risk profile.
• Convenient strength for maintenance: the 125 mg tablet lets eligible adults take one tablet twice daily after the initiation phase.
• Made by a WHO-GMP and ISO-certified manufacturer: Steris Healthcare Pvt. Ltd. manufactures under quality-assured systems.

Dosage and How to Take BOSENTIME 125

• Starting dose (adults): usually 62.5 mg twice daily for the first 4 weeks.
• Maintenance dose (adults over 40 kg): usually 125 mg twice daily (morning and evening), which is where BOSENTIME 125 is used.
• Adults under 40 kg: the doctor typically keeps the dose at 62.5 mg twice daily.
• Higher doses: doses above 125 mg twice daily have not been shown to add benefit and may raise liver-related risk.
• Timing: take one tablet in the morning and one in the evening, about 12 hours apart, with or without food, swallowed with water.
• Consistency: keep the same times every day and do not skip doses.
• Missed dose: take it as soon as you remember. If it is nearly time for the next dose, skip the missed one. Never double up.
• Stopping: do not stop suddenly. Your doctor may reduce the dose gradually to avoid worsening of symptoms.

Monitoring You Should Expect

• Liver function tests (ALT/AST): before starting and every month while on treatment.
• Haemoglobin: before starting, monthly for the first 4 months, then periodically.
• Pregnancy tests: monthly for women who can become pregnant.
• Specialist review: regular follow-up including symptom and functional assessment.

Side Effects of Bosentan

Not everyone gets side effects, and many are manageable when found early.

Common side effects

• Headache
• Flushing
• Swelling of the ankles or feet (fluid retention)
• Nasal congestion or a sore throat
• Indigestion or acid reflux
• Palpitations or low blood pressure
• Tiredness

Serious side effects: contact your doctor promptly

• Liver injury: yellowing of the skin or eyes, dark urine, pain in the upper right abdomen, unusual tiredness, nausea, vomiting, or fever.
• Anaemia: unusual paleness, weakness or worsening breathlessness.
• Marked fluid retention: rapid weight gain, significant swelling or worsening shortness of breath.
• Allergic reactions: rash, itching, swelling of the face or lips.
• Sudden worsening of breathlessness with fluid in the lungs: needs urgent evaluation.
• Birth defects: if taken during pregnancy.

Precautions and Who Should Not Take Bosentan

Do not take bosentan if you:

• are pregnant or planning pregnancy
• have moderate or severe liver impairment, or liver enzymes well above the normal range at baseline
• are taking cyclosporine or glibenclamide (glyburide)
• are allergic to bosentan or any ingredient in the tablet

Tell your doctor before starting if you:

• have any liver disease, anaemia, heart failure or low blood pressure
• take other medicines, especially rifampicin, ritonavir-containing regimens, ketoconazole/itraconazole/fluconazole, sildenafil, warfarin or statins (bosentan can change the levels of these and may be affected by them)
• use hormonal contraceptives (pills, patches, implants, injections). Bosentan may make them less reliable, so your doctor will advise a suitable method
• are breastfeeding. This is generally not recommended during treatment

Practical safety tips

• Never share the tablets and do not restart from an old prescription without review.
• Keep a written record of monthly blood test dates.
• Carry a card or note listing the medicine and dose in case of emergency.

Bosentan vs Other PAH Medicines: 

Feature	Bosentan (BOSENTIME 125)	Ambrisentan	Macitentan	PDE-5 inhibitors (sildenafil / tadalafil)
Drug class	Dual endothelin receptor antagonist	Selective ET-A antagonist	Dual endothelin receptor antagonist	Phosphodiesterase-5 inhibitor
Usual dosing frequency	Twice daily	Once daily	Once daily	Varies (sildenafil several times daily, tadalafil once daily)
Regular liver monitoring	Yes, monthly	Per current labelling	Per current labelling	Not routinely required
Pregnancy	Contraindicated	Contraindicated	Contraindicated	Different risk profile; doctor to advise
Often used with	PDE-5 inhibitors (specialist decision)	PDE-5 inhibitors	PDE-5 inhibitors	ERAs

Where to Buy BOSENTIME 125 and How to Check Price in India

Because bosentan is a Schedule H medicine with mandatory monitoring, it should be obtained through a valid prescription and a trusted, licensed channel. Here is a simple way to check price and availability:

1. Keep your prescription ready. It should mention the brand or generic name (bosentan), the strength (125 mg) and the dose schedule.
2. Contact Steris Healthcare. Call or write to the team listed below and share the strength, pack size (10 tablets) and delivery city.
3. Confirm availability and price. Ask for the current price per strip and the nearest authorised supply point.
4. Verify the pack on receipt. Check the brand name, composition, batch number, manufacturing and expiry dates.
5. Continue the monitoring plan. Book your next liver test and follow-up before the strip finishes.

Conclusion

BOSENTIME 125 (bosentan 125 mg) is a maintenance-strength endothelin receptor antagonist tablet from Steris Healthcare Pvt. Ltd. for adults with pulmonary arterial hypertension. Its benefits come from steady, twice-daily use, strict avoidance in pregnancy and regular blood monitoring. The most useful steps are to keep your specialist follow-ups, tell every doctor and pharmacist that you take bosentan, and obtain the medicine with a valid prescription from a reliable source. When you are ready, use the contact details above to check price and availability.

Frequently Asked Questions 

1. Where can I buy bosentan online?

Bosentan is a prescription-only medicine, so it should be obtained on a valid prescription from a licensed source. For BOSENTIME 125, you can send an enquiry to Steris Healthcare through sterisonline.com or the phone numbers listed above to check price and the nearest authorised supply point.

2. What is the price of bosentan?

The price depends on the brand, strength and pack size. For BOSENTIME 125 (bosentan 125 mg, strip of 10 tablets), please contact Steris Healthcare for the current price. [MRP placeholder – to be inserted by Steris.]

3. Can I order bosentan online?

You can start an enquiry online, but as bosentan is a Schedule H drug, supply is made only against a valid prescription. Share your prescription with the Steris team or an authorised pharmacy when you place your order.

4. Is bosentan available from Steris Healthcare?

Yes. Steris Healthcare Pvt. Ltd. markets bosentan as BOSENTIME 125 (125 mg) and BOSENTIME 62.5 (62.5 mg). Contact the team for current availability.

5. What is bosentan used for?

Bosentan is used to treat pulmonary arterial hypertension (PAH) in adults to improve exercise capacity and reduce symptoms. Some approved labelling also lists reducing new digital ulcers in systemic sclerosis.

6. What is the composition of bosentan (BOSENTIME 125)?

Each BOSENTIME 125 tablet contains bosentan 125 mg. Bosentan is a dual endothelin receptor antagonist.

7. Is a prescription required for bosentan?

Yes. Bosentan is a Schedule H medicine and must be used under the supervision of a doctor, usually a cardiologist or pulmonologist experienced in PAH.

8. How should bosentan be taken?

Adults usually take one tablet twice daily, morning and evening, with or without food. The starting dose is normally lower (62.5 mg twice daily) for four weeks before moving to 125 mg twice daily. Follow your doctor's schedule.

9. What should I know before buying bosentan?

Confirm the strength on your prescription, and check that you are not pregnant and not taking cyclosporine or glibenclamide. Plan for monthly liver tests, check the pack details and buy only from a licensed source.

10. How can I order bosentan online?

Keep your prescription ready, contact Steris Healthcare via the website, phone or email, confirm strength (125 mg), pack size (10 tablets), price and delivery city, and then verify the pack on receipt.

11. What are the common side effects of bosentan?

Headache, flushing, swelling of the feet or ankles, nasal congestion, indigestion and abnormal liver tests are commonly reported. Report yellowing of the eyes or skin, dark urine or severe tiredness to your doctor immediately.

12. Why are liver tests needed with bosentan?

Bosentan can raise liver enzymes and, rarely, cause liver injury. Liver function is checked before treatment and monthly afterwards so that the dose can be adjusted or the medicine stopped early if needed.

13. Is bosentan safe in pregnancy? No. Bosentan can cause serious birth defects and must not be used during pregnancy. Women who can become pregnant need a negative pregnancy test before starting, monthly tests and reliable contraception, as advised by their doctor.

14. What is the difference between BOSENTIME 62.5 and BOSENTIME 125?

Both contain bosentan. BOSENTIME 62.5 (62.5 mg) is typically used for the initial four weeks in adults and for lower-weight patients, while BOSENTIME 125 (125 mg) is the usual adult maintenance strength. Your doctor decides which one you need.

15. Can bosentan be taken with sildenafil or tadalafil?

Specialists sometimes combine bosentan with a PDE-5 inhibitor. Bosentan can lower sildenafil levels and sildenafil can raise bosentan levels, so combination therapy should only be done on a doctor's prescription with monitoring.

16. What should I do if I miss a dose of bosentan?

Take it when you remember, unless it is almost time for the next dose. Do not take two doses together.

17. Can I stop bosentan suddenly?

No. Stopping abruptly may lead to worsening of PAH symptoms. Speak to your doctor, who may reduce the dose gradually.

18. Does bosentan affect birth control pills?

Yes. Bosentan may reduce the effectiveness of hormonal contraceptives, so they should not be the only method used. Your doctor will suggest a suitable option.

19. How should BOSENTIME 125 be stored?

Store the strip as directed on the pack, in its original packaging, away from moisture, heat and direct sunlight, and out of reach of children.