Telmisartan 40 mg & Nebivolol 5 mg`````

Hypertension, commonly known as high blood pressure, is one of the most widespread lifestyle-related disorders in India. Rapid urbanisation, increasing stress levels, unhealthy dietary habits, obesity, lack of physical activity, and genetic predisposition have significantly contributed to the growing burden of hypertension across all age groups. What makes high blood pressure particularly dangerous is that it often shows no obvious symptoms, yet it silently increases the risk of heart attack, stroke, kidney disease, and heart failure.

In many patients, controlling blood pressure with a single medicine is not sufficient. Such individuals often require combination therapy that targets multiple mechanisms involved in blood pressure regulation. Modern hypertension management focuses not only on lowering blood pressure numbers but also on providing long-term cardiovascular protection with good tolerability.

TELMISTRUM NEBI 40-5 is a scientifically formulated fixed-dose combination of Telmisartan 40 mg and Nebivolol 5 mg, designed to provide comprehensive blood pressure control. Telmisartan, an Angiotensin II Receptor Blocker (ARB), relaxes blood vessels and protects vital organs, while Nebivolol, a highly selective beta-blocker with nitric oxide–mediated vasodilatory action, slows the heart rate and improves vascular function.

Together, TELMISTRUM NEBI 40-5 offers powerful, balanced, and sustained blood pressure control while supporting heart health and overall cardiovascular safety.

Uses of TELMISTRUM NEBI 40-5

TELMISTRUM NEBI 40-5 is primarily prescribed for the management of hypertension and related cardiovascular conditions.

1. Treatment of Hypertension

This combination is used to:

• Lower elevated blood pressure

• Maintain stable blood pressure throughout the day

• Reduce stress on the heart and blood vessels

It is especially useful for patients whose blood pressure is not adequately controlled with monotherapy.

2. Hypertension with High Heart Rate

Nebivolol helps control heart rate, making TELMISTRUM NEBI 40-5 suitable for patients with:

• Elevated pulse rate

• Stress-related hypertension

• Cardiovascular strain due to increased sympathetic activity

3. Cardiovascular Risk Reduction

By controlling blood pressure and improving vascular function, TELMISTRUM NEBI 40-5 helps reduce the risk of:

• Heart attack

• Stroke

• Heart failure

• Left ventricular hypertrophy

4. Hypertension in Diabetic and Metabolic Syndrome Patients

Telmisartan has metabolic neutrality and kidney-protective effects, making this combination beneficial for patients with:

• Type 2 diabetes

• Obesity

• Metabolic syndrome

Benefits of TELMISTRUM NEBI 40-5

TELMISTRUM NEBI 40-5 provides multiple therapeutic benefits due to its complementary mechanism of action.

1. Dual Mechanism for Superior Blood Pressure Control

• Telmisartan blocks the action of angiotensin II, relaxing blood vessels and reducing fluid retention.

• Nebivolol lowers heart rate and promotes nitric oxide–mediated vasodilation.

This dual action ensures effective and sustained blood pressure reduction.

2. 24-Hour Blood Pressure Stability

TELMISTRUM NEBI 40-5 provides:

• Long-lasting antihypertensive effect

• Reduced morning blood pressure surge

• Improved day-long blood pressure control

3. Heart Rate and Cardiac Workload Reduction

Nebivolol helps:

• Reduce heart rate

• Decrease myocardial oxygen demand

• Improve cardiac efficiency

This is especially beneficial in patients with cardiac risk factors.

4. Excellent Tolerability Profile

Compared to traditional beta-blockers, Nebivolol:

• Causes fewer metabolic side effects

• Has less impact on sexual function

• Is better tolerated in elderly patients

5. Kidney and Vascular Protection

Telmisartan offers:

• Renal protection, especially in diabetics

• Reduced progression of kidney damage

• Improved endothelial function

6. Improved Patient Compliance

The fixed-dose combination:

• Reduces pill burden

• Simplifies daily treatment

• Enhances long-term adherence

Dosage of TELMISTRUM NEBI 40-5

Recommended Dosage

• One tablet once daily, or as prescribed by the physician

• Can be taken with or without food

• Should be taken at the same time each day for best results

Dose Individualisation

Dosage may be adjusted based on:

• Blood pressure response

• Heart rate

• Age of the patient

• Kidney and liver function

• Co-existing medical conditions

Missed Dose

• Take the missed dose as soon as remembered

• Skip it if it is close to the next scheduled dose

• Do not double the dose

⚠️ Regular blood pressure and pulse monitoring are advised during treatment.

Side Effects of TELMISTRUM NEBI 40-5

Telmisartan 40 mg & Nebivolol 5 mg is generally well tolerated. However, some patients may experience mild to moderate side effects.

Common Side Effects

• Dizziness or lightheadedness

• Fatigue

• Headache

• Slow heart rate

• Cold hands or feet

Less Common Side Effects

• Nausea

• Sleep disturbances

• Mild breathlessness

• Gastrointestinal discomfort

Rare but Serious Side Effects

• Excessive drop in blood pressure

• Severe bradycardia

• Worsening of heart failure (rare)

• Allergic reactions

If severe or persistent side effects occur, medical attention should be sought immediately.

Warnings and Safety Information

Low Blood Pressure Risk

Patients with dehydration or on diuretics should use TELMISTRUM NEBI 40-5 cautiously.

Heart Conditions

Use with caution in patients with:

• Severe bradycardia

• Advanced heart block

• Uncontrolled heart failure

Respiratory Conditions

Although Nebivolol is cardioselective, caution is advised in patients with asthma or chronic obstructive pulmonary disease.

Pregnancy and Breastfeeding

• Not recommended during pregnancy

• Use during breastfeeding only if advised by a doctor

Diabetes

Nebivolol may mask symptoms of hypoglycaemia; blood sugar monitoring is advised.

Precautions

• Inform your doctor about all medicines you are taking

• Avoid sudden discontinuation of therapy

• Limit alcohol consumption

• Maintain a low-salt, heart-healthy diet

• Monitor blood pressure and pulse regularly

• Follow lifestyle modifications such as exercise and weight management

Conclusion

TELMISTRUM NEBI 40-5 is a well-balanced and effective combination therapy for patients with hypertension requiring enhanced blood pressure control and cardiovascular protection. By combining Telmisartan 40 mg and Nebivolol 5 mg, it addresses both vascular resistance and cardiac workload, ensuring stable, long-lasting blood pressure management.

With its excellent tolerability, once-daily dosing, and added heart-protective benefits, TELMISTRUM NEBI 40-5 is a reliable choice for long-term hypertension management. When combined with healthy lifestyle practices and regular medical follow-up, it plays a vital role in reducing the risk of serious cardiovascular complications and improving overall quality of life.

Frequently Asked Questions (FAQs)

Q1. What is TELMISTRUM NEBI 40-5 used for?

It is used to treat high blood pressure and reduce cardiovascular risk by combining an ARB and a beta-blocker.

Q2. Is TELMISTRUM NEBI 40-5 suitable for long-term use?

Yes, it is designed for long-term management of hypertension under medical supervision.

Q3. Does this medicine affect heart rate?

Yes, Nebivolol helps lower heart rate, which reduces cardiac workload.

Q4. Can diabetic patients take TELMISTRUM NEBI 40-5?

Yes, it is commonly prescribed for diabetic patients, but blood sugar monitoring is advised.

Q5. Can I stop taking this medicine once my BP is normal?

No. Stopping suddenly can cause blood pressure rebound. Always consult your doctor before discontinuation.

Q6. Does it cause cough like some BP medicines?

No, Telmisartan does not usually cause dry cough.