Sacubitril (49mg) & Valsartan (51mg)
May 26, 2023
Sacubitril (49mg), Valsartan (51mg)
SACUBRIGHT is a medication that combines two active ingredients: sacubitril and valsartan. It is used in the treatment of heart failure with reduced ejection fraction (HFrEF).
Sacubitril inhibits an enzyme called neprilysin, which breaks down various peptides, including natriuretic peptides. By inhibiting neprilysin, sacubitril increases the levels of natriuretic peptides, which leads to vasodilation (widening of blood vessels) and decreased sodium and fluid retention. These effects help reduce the workload on the heart and improve cardiac function.
Valsartan is an ARB that blocks the action of angiotensin II, a hormone that constricts blood vessels and stimulates the release of aldosterone, leading to increased fluid retention. By blocking angiotensin II receptors, valsartan helps dilate blood vessels, reduce fluid retention, and lower blood pressure.
SACUBRIGHT as a combination based medication allows for a dual mechanism of action, resulting in improved clinical outcomes in patients with HFrEF. SACUBRIGHT has been shown to reduce the risk of cardiovascular death and hospitalizations related to heart failure.
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