Ursodeoxycholic Acid (450 mg) .. . .. . . .

Feb 27, 2024

UDCHOLIC SR 450 
 Ursodeoxycholic Acid (450 mg)
UDCHOLIC SR 450  is a naturally occurring bile acid that is used for the treatment of various liver and gallbladder conditions. Unlike other bile acids, UDCHOLIC SR 450 is considered to have protective properties for liver cells and is used both to manage diseases and to improve liver function in certain conditions.
Mechanism of Action:
UDCHOLIC SR 450  works by several mechanisms, depending on the condition being treated:

Decreasing Cholesterol Absorption and Dissolving Gallstones: UDCHOLIC SR 450  reduces the cholesterol content of bile by decreasing the synthesis and absorption of cholesterol, which can help dissolve gallstones made of cholesterol.
Protecting Liver Cells: It increases the flow of bile, which helps protect liver cells from bile acid-induced damage. This is particularly beneficial in conditions where bile flow is reduced or obstructed.
Immunomodulatory Effects:UDCHOLIC SR 450 has been shown to have immune-modulating effects, which can be beneficial in autoimmune liver diseases.
Uses:
UDCA is used for the treatment of several conditions, including:

Primary Biliary Cholangitis (PBC): A chronic liver disease where bile ducts in the liver are gradually destroyed. UDCA is the first-line treatment for PBC and can improve liver function tests and delay disease progression.
Gallstones: For patients who cannot undergo surgery, UDCA can be used to dissolve small, cholesterol-rich gallstones.
Primary Sclerosing Cholangitis (PSC): Although not a cure, UDCA is sometimes used off-label for PSC, a condition that causes inflammation and scarring of the bile ducts.
Cholestasis of Pregnancy: UDCA can relieve itching and improve liver tests in pregnant women with this condition.
Dosage and Administration:
The dosage of UDCA varies depending on the condition being treated, ranging from 250 mg to 15 mg/kg/day, usually divided into two to three doses daily. It's important to follow the prescribing physician's instructions closely, as the treatment duration and dosage may vary significantly based on individual needs and response to therapy.

Side Effects:
UDCA is generally well-tolerated, but side effects can occur, including:

Diarrhea
Nausea
Upset stomach
Rash
Considerations:
Pregnancy and Breastfeeding: UDCA is considered safe during pregnancy and breastfeeding for specific conditions like intrahepatic cholestasis of pregnancy, but it should only be used under the guidance of a healthcare provider.
Gallstones: UDCA is effective only for cholesterol stones and not for bilirubin stones. It's also not suitable for patients with calcified gallstones, non-functioning gallbladders, or frequent gallstone complications.
Interaction with Other Drugs:
UDCA can interact with certain medications, affecting its absorption or effectiveness. It's essential to inform healthcare providers about all medications and supplements being taken to avoid potential interactions.
In managing conditions with UDCA, regular monitoring through liver function tests and possibly imaging studies is necessary to assess response to treatment and adjust dosages as needed.
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