Dapagliflozin (5mg), Metformin (500mg)

Diabetes is one of the fastest-growing lifestyle disorders in India, affecting people across all age groups. With changing food habits, sedentary lifestyles, obesity, and genetic predisposition, Type 2 Diabetes Mellitus has become a major public health challenge. Effective diabetes management today focuses not just on lowering blood sugar, but also on improving insulin sensitivity, protecting vital organs, and reducing long-term complications.

GLIDAPAFLOZIN M 5/500 is a modern combination antidiabetic medicine containing Dapagliflozin 5 mg and Metformin 500 mg, designed to provide dual-action blood glucose control. It is commonly prescribed for patients whose blood sugar levels are not adequately controlled with diet, exercise, or single-drug therapy.

This detailed article explains everything about GLIDAPAFLOZIN M 5/500, including its composition, working mechanism, uses, benefits, dosage, side effects, precautions, and FAQs.

Introduction to GLIDAPAFLOZIN M 5/500

GLIDAPAFLOZIN M 5/500 is an oral antidiabetic tablet used in the management of Type 2 Diabetes Mellitus. It combines two well-established medicines with complementary mechanisms of action:

• Dapagliflozin – promotes glucose excretion through urine

• Metformin – improves insulin sensitivity and reduces glucose production in the liver

This combination helps control both fasting and post-meal blood sugar levels, making it an effective option for long-term diabetes management.

GLIDAPAFLOZIN M 5/500 is especially useful for patients who need better glycaemic control without excessive weight gain or frequent hypoglycaemia.

Composition of GLIDAPAFLOZIN M 5/500

Each tablet contains:

• Dapagliflozin 5 mg

• Metformin Hydrochloride 500 mg

Together, these ingredients work synergistically to improve glucose control and overall metabolic health.

Understanding the Key Ingredients

Dapagliflozin 5 mg

Dapagliflozin belongs to the class of medicines called SGLT2 inhibitors (Sodium-Glucose Co-Transporter 2 inhibitors). It works by:

• Preventing reabsorption of glucose in the kidneys

• Increasing glucose excretion through urine

• Lowering blood sugar levels independent of insulin

Dapagliflozin also provides additional benefits such as mild weight reduction and cardiovascular protection.

Metformin 500 mg

Metformin is a biguanide and is considered the cornerstone of type 2 diabetes treatment. It works by:

• Reducing glucose production in the liver

• Improving insulin sensitivity in muscles

• Enhancing glucose uptake by body tissues

• Helping maintain or reduce body weight

Metformin has been used safely for decades in Indian patients.

How GLIDAPAFLOZIN M 5/500 Works

GLIDAPAFLOZIN M 5/500 offers dual glucose control through complementary pathways:

• Dapagliflozin removes excess glucose via urine

• Metformin reduces glucose production and improves insulin response

• Together, they lower fasting and postprandial blood sugar

• Helps improve HbA1c levels over time

This insulin-independent action reduces the risk of severe hypoglycaemia compared to some older diabetes medicines.

Uses of GLIDAPAFLOZIN M 5/500 Tablet

GLIDAPAFLOZIN M 5/500 is prescribed for:

Type 2 Diabetes Mellitus

Used when:

• Blood sugar is not controlled with diet and exercise alone

• Single-drug therapy is insufficient

• Combination therapy is required for better control

Insulin Resistance

Improves insulin sensitivity and glucose utilization.

Overweight or Obese Diabetic Patients

Helps support weight management alongside blood sugar control.

Prevention of Diabetes-Related Complications

Consistent glucose control helps reduce the risk of:

• Heart disease

• Kidney damage

• Nerve damage

• Eye complications

Benefits of GLIDAPAFLOZIN M 5/500

Effective Blood Sugar Control

Controls both fasting and post-meal glucose levels.

Dual Mechanism of Action

Targets glucose production and glucose excretion simultaneously.

Lower Risk of Hypoglycaemia

Does not overstimulate insulin release.

Weight-Friendly Diabetes Management

Helps prevent weight gain and may support mild weight loss.

Cardiovascular and Renal Benefits

Dapagliflozin is known to support heart and kidney health in diabetic patients.

Improved HbA1c Levels

Supports long-term glycaemic control.

Dosage of GLIDAPAFLOZIN M 5/500

Recommended Dosage

• As prescribed by the doctor

• Usually once or twice daily with meals

How to Take

• Take with food to reduce stomach discomfort

• Swallow whole with water

• Do not crush or chew

Dose Adjustment

Dosage may be adjusted based on:

• Blood sugar levels

• Kidney function

• Age and overall health

Regular blood glucose monitoring is essential.

Missed Dose and Overdose

Missed Dose

• Take it as soon as you remember

• Skip if it’s close to the next dose

• Do not double the dose

Overdose

Overdose may increase the risk of dehydration, low blood sugar, or lactic acidosis. Seek immediate medical attention if symptoms such as dizziness, rapid breathing, weakness, or confusion occur.

Side Effects of GLIDAPAFLOZIN M 5/500

Most patients tolerate GLIDAPAFLOZIN M 5/500 well.

Common Side Effects

• Increased urination

• Mild nausea

• Diarrhoea

• Stomach discomfort

Genital or Urinary Infections

Due to increased glucose in urine, some patients may experience:

• Urinary tract infections

• Genital fungal infections

Maintaining good hygiene and hydration helps reduce this risk.

Rare but Serious Side Effects

• Dehydration

• Lactic acidosis (very rare)

• Low blood pressure

Consult a doctor if any severe symptoms occur.

Precautions and Warnings

Kidney Disease

Dose adjustment or avoidance may be required in severe kidney impairment.

Dehydration

Drink adequate fluids, especially in hot Indian climates.

Alcohol Consumption

Avoid excessive alcohol intake.

Elderly Patients

Monitor kidney function and hydration status.

Pregnancy and Breastfeeding

Use only if clearly advised by a doctor.

Drug Interactions

GLIDAPAFLOZIN M 5/500 may interact with:

• Diuretics

• Blood pressure medicines

• Other antidiabetic drugs

• Steroids

• Alcohol

Always inform your doctor about all medicines and supplements you are taking.

Lifestyle Advice for Better Results

For best results with GLIDAPAFLOZIN M 5/500:

• Follow a balanced diabetic diet

• Exercise regularly

• Monitor blood sugar levels

• Maintain healthy body weight

• Avoid smoking and excessive alcohol

Storage Instructions

• Store below 25°C

• Keep away from moisture and direct sunlight

• Keep out of reach of children

Why Choose GLIDAPAFLOZIN M 5/500?

GLIDAPAFLOZIN M 5/500 offers:

• Modern dual-action diabetes control

• Improved insulin sensitivity

• Cardiovascular and renal protection

• Convenient dosing

• Better quality of life for diabetic patients

It is a trusted option for patients requiring effective and balanced glycaemic management.

Conclusion

GLIDAPAFLOZIN M 5/500 Tablet, containing Dapagliflozin 5 mg and Metformin 500 mg, is an effective and well-tolerated treatment for Type 2 Diabetes Mellitus. Its dual-mechanism approach ensures comprehensive blood sugar control while supporting weight management and long-term metabolic health.

Frequently Asked Questions 

What is GLIDAPAFLOZIN M 5/500 used for?

It is used to treat type 2 diabetes mellitus.

Does GLIDAPAFLOZIN M 5/500 cause weight gain?

No, it is weight-neutral and may support mild weight loss.

Can GLIDAPAFLOZIN M 5/500 cause low blood sugar?

Risk is low when used alone, but caution is needed with other antidiabetic medicines.

Is it safe for long-term use?

Yes, when taken under medical supervision.

Can elderly patients take this medicine?

Yes, with proper monitoring of kidney function.

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We Have Our Diabetic Range.

Composition	Brand Name
dapagliflozin and metformin hydrochloride extended-release	GLIDAPAFLOZIN M 10/500
dapagliflozin and metformin	GLIDAPAFLOZIN M 10/1000
Dapagliflozin (5mg) And Metformin (1000mg)	GLIDAPAFLOZIN M 5/ 1000
dapagliflozin 10 mg	GLIDAPAFLOZIN 10
dapagliflozin 5 mg	GLIDAPAFLOZIN 5