Comprehensive Guide to Magral 40: Megestrol Acetate 40 mg

Introduction

MAGRAL 40 is a pharmaceutical formulation containing Megestrol Acetate 40 mg, a synthetic progestin with potent antineoplastic and appetite-stimulating properties. It is widely used in the treatment of advanced breast cancer, endometrial carcinoma, and appetite loss associated with cancer or AIDS-related cachexia. With its favorable efficacy and tolerability profile, MAGRAL 40 has become a trusted therapy in oncology and palliative care.

Composition

Each tablet of MAGRAL 40 contains:

• Megestrol Acetate – 40 mg

• Excipients – q.s.

Mechanism of Action

Megestrol acetate, a derivative of progesterone, works primarily through:

• Hormonal modulation: It binds to progesterone receptors and alters hormone levels, thereby inhibiting the growth of hormone-sensitive tumors (e.g., breast or endometrial cancer).

• Appetite stimulation: It affects the hypothalamic-pituitary axis to enhance appetite and promote weight gain, particularly useful in cancer cachexia and HIV-related wasting syndrome.

Indications and Uses

MAGRAL 40 (Megestrol Acetate 40 mg) is prescribed for:

1. Breast Cancer (Hormone Receptor Positive, Advanced or Metastatic)

2. Endometrial Cancer

3. Appetite Stimulation in Cachexia (especially in patients with cancer or HIV/AIDS)

4. Palliative Management of Anorexia or Weight Loss

Dosage and Administration

Recommended Dosage:

• Cancer Therapy:
  160 mg to 320 mg per day in divided doses (i.e., 4–8 tablets of MAGRAL 40), or as directed by an oncologist.

• Appetite Stimulation/Cachexia:
  Typically 400–800 mg/day in divided doses. Start with a lower dose and titrate based on response and tolerance.

Administration Tips:

• Administer orally with or without food.

• Consistency in timing (e.g., morning and evening) improves therapeutic outcomes.

• Continue therapy as advised by the treating physician, even if appetite improves.

Note: Always follow the dose recommended by your healthcare provider. Dosage may vary based on the condition being treated, age, and overall patient health.

Side Effects of Megestrol Acetate

Like all medications, MAGRAL 40 may cause side effects, though not everyone experiences them. Common and serious side effects include:

Common Side Effects:

• Increased appetite and weight gain

• Nausea or vomiting

• Bloating or gas

• Fluid retention (edema)

• Insomnia or mood changes

• Menstrual irregularities

Serious Side Effects (Seek medical attention):

• Deep vein thrombosis (DVT): Leg pain, swelling

• Pulmonary embolism: Chest pain, shortness of breath

• Adrenal suppression (in long-term use)

• Hyperglycemia in diabetic patients

Contraindications

• Known hypersensitivity to Megestrol or any component of the formulation

• Pregnant women (Category X – can cause fetal harm)

• History of thromboembolic disorders (unless benefits outweigh risks)

Precautions and Warnings

• Use in elderly: Monitor closely for thromboembolic events and fluid retention.

• Diabetics: May require insulin dose adjustment due to increased blood sugar levels.

• Hormone-sensitive conditions: Use under strict medical supervision.

• Long-term use: May suppress the adrenal axis; taper gradually if discontinuing.

• Pediatric use: Not recommended unless clearly indicated.

Drug Interactions

Megestrol Acetate may interact with:

• Warfarin and other anticoagulants: May alter INR levels

• Insulin or oral hypoglycemics: May increase blood glucose

• Corticosteroids: Additive risk of adrenal suppression

Storage Information

• Store below 25°C in a dry, cool place.

• Protect from direct light and moisture.

• Keep out of reach of children.

Frequently Asked Questions (FAQs)

Q1. What is MAGRAL 40 used for?

MAGRAL 40 is used to treat advanced breast or endometrial cancer and to improve appetite and weight gain in patients suffering from cachexia due to cancer or AIDS.

Q2. Is Megestrol Acetate a steroid?

Yes, it is a synthetic derivative of the hormone progesterone, but it is not an anabolic steroid.

Q3. Can MAGRAL 40 be used for weight gain in non-cancer patients?

It is primarily used for medically indicated weight gain in serious conditions like cancer or HIV. Off-label use should only be done under physician supervision.

Q4. Is it safe to take during pregnancy?

No. Megestrol Acetate is contraindicated in pregnancy as it may harm the unborn baby.

Q5. How long does it take to see the effects on appetite?

Most patients notice an improvement in appetite within 1–2 weeks of starting therapy.

Conclusion

MAGRAL 40 (Megestrol Acetate 40 mg tablet) is a reliable and clinically proven option for managing hormone-sensitive cancers and combating cachexia-related malnutrition. It offers dual benefits as an oncologic agent and an appetite stimulant, enhancing both survival and quality of life in patients battling serious illnesses.Always use MAGRAL 40 under medical guidance to ensure safety, optimal dosage, and monitoring for potential side effects.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

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